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Post-doctoral position in Mass spectrometry data analyst – Natural Extract characterization
Working time: 100%. Contract duration: Minimum 1 year. Employment date: ASAP.
Innovative data mining strategies for natural extracts metabolomics, natural products dereplication and bioactives identification.
Project description and key responsibilities
Plants and microorganisms are sources of potential biologically active compounds. Accumulated via secondary metabolism pathways, these potent chemicals could exhibit a wide variety of structures and physicochemical properties making their identification amongst hundreds of molecules present in natural extracts more complex. If data acquisition on natural extracts constituents is no longer considered an obstacle thanks to the latest development in terms of analytical platforms (e.g. ultra-high-performance chromatographic approaches, high-resolution mass spectrometry (HRMS)), data processing, however, still is a real barrier to efficient extracts characterization and rapid identification of potential new bioactive entities.
In this context, the Post-Doc candidate will first focus on setting up an efficient and automated procedure for post-acquisition data deconvolution and treatment aiming at the constitution of a natural compounds spectral database. In a second instance, the candidate will investigate and further develop processing strategies and dereplication tools for the characterization of complex natural matrices metabolome and putative identification of new bioactive species from HRMS data. Finally, as an advisor of NIHS Natural Bioactives and Screening department, the candidate will insure both translation and integration of her/his findings and developments to the department workflow including the analytical data implementation within the department in-house natural products library.
Education and experience
The candidate holds a PhD degree in pharmaceutical sciences, phytochemistry, chemoinformatics, chemistry or equivalent. Proven experience in computational mass spectrometry and proficiency in related software suites are mandatory. Programming skills in R and SQL coding constitute a key asset. Good understanding of practical chromatography and mass spectrometry are required. The ideal candidate is
highly motivated, inventive, team player, well organized and has very good oral and written communication skills in English.
The project is framed in a fruitful collaboration established in 2014 between the Nestlé Institute of Health Sciences (NIHS) and the School of Pharmacy of the University of Geneva. Located in the heart of Geneva, the Phytochemistry & Bioactive Natural Products research unit of School of Pharmacy has a strong expertise plant metabolomics and bioactives identification ( http://www.unige.ch/sciences/pharm/fasie). NIHS has recently been established to deliver world class excellence in biomedical research to better understand health and disease with the goal of translating this knowledge into personalized science‐based nutrition. Located less than 1 km away from the Geneva Lake, on the Swiss Federal Institute of Technology (EPFL) campus in Lausanne, NIHS ( http://www.nestleinstitutehealthsciences.com/) offers a truly innovative and international working environment fostering academic research. As part of NIHS, the Natural Bioactives & Screening Department aims to identify new natural bioactives of interest for metabolic, gastrointestinal, and brain health. Both working locations are easily accessible and commutable by public transport. English is the working language.
Prof. Jean-Luc Wolfender, Dr. Emerson Ferreira Queiroz, Dr. Pierre-Marie Allard (University of Geneva) Dr Denis Barron, Dr Alexandre Grand-Guillaume-Perrenoud (NIHS)
Daily work will take place at NIHS. Regular interactions with University of Geneva including traveling are planned on a weekly up to monthly basis.
The salary will follow the University of Geneva School of Pharmacy standards.
Position: PhD or equivalent; demonstrated experience in chemical syntheses, particularly derivatization chemistry for tagging biomarkers to enhance analyte detection by LC/MS; mass spectrometric characterization of biomarkers in complex biological matrices and application to trace quantitative analysis of biomarkers in vivo. Hands-on-training in liquid chromatography/mass spectrometry of biomarkers, sample preparation and workup, analytical chemistry, bioinformatics, LC, MS, and MS/MS techniques, employing triple quadrupole, ion trap and high resolution MS instruments for human biomonitoring DNA adducts and protein adducts.
Preferred qualifications: PhD with research in Bioanalytical mass spectrometry. Prior experience in chemical syntheses, analytical chemistry; sample workup, chemical biomarkers, experience in maintaining LC/S instrumentation, and hands-on-training in liquid chromatography/mass spectrometry of biomarkers, including, urinary biomarkers, protein- or DNA carcinogen adducts. Experience with LC/MS employing nanoLC and nanospray sources are desired.
The University of Minnesota is an equal opportunity educator and employer.
Interested individuals are encouraged to apply at http://humanresources.umn.edu/jobs. Submit a statement of research interests, curriculum vitae, and list of references to job number 316527. Contact: Dr. Robert J. Turesky, Masonic Cancer Center, University of Minnesota (Tel: 612-626-0141; Email: rturesky(at)umn(dot)edu). The University of Minnesota is an equal opportunity employer.
Halle (Saale), 04.04.2017
An der Martin-Luther-Universität Halle-Wittenberg, Medizinische Fakultät, Zentrum für Medizinische Grundlagenforschung (ZMG), ist ab dem nächstmöglichen Zeitpunkt die auf bis zu 2 Jahre befristete Stelle einer/eines:
Leiterin/Leiters der Core Facility “Protein Massenspektrometrie”
mit der Option auf Entfristung zu besetzen.
Die Befristung erfolgt gemäß § 14 Absatz 2 TzBfG (Teilzeit- und Befristungsgesetz), demnach können nur Bewerberinnen
und Bewerber berücksichtigt werden, die bislang noch nicht in einem Arbeitsverhältnis mit dem Land Sachsen-Anhalt
Vollzeitbeschäftigung (100,0 %)
Die Vergütung erfolgt je nach Aufgabenübertragung und Erfüllung der persönlichen Voraussetzungen bis zur Entgeltgruppe 13 TV-L.
- Promotion in Chemie, Biochemie, Biologie, Pharmazie oder einem verwandten Fach
- Exzellente Erfahrungen in MS-basierter Proteom Analyse (Protein Identifikation und Quantifizierung) und in der
- Analyse von post-translationalen Modifikationen
- Erfahrungen in der Planung, Entwicklung, und Validierung von qualitätskontrollierten Proteom Analysen (Proben
- Präparation, MS Analyse, Daten Analyse)
- Erfahrungen als Projekt Manager/in / Team Leiter/in
- Exzellentes Wissenschaftsenglisch (Lesen, Schreiben, Verständigung)
- Entwicklung und Etablierung Massenspektrometrie-basierter Proteom Analysen von Zellen, Geweben und Körperflüssigkeiten
- Entwicklung neuer Protokolle für Probenpräparationen und Protein MS Analysen aus komplexen Proben (Biomarker Entwicklung)
- Leitung eines Teams
- Nationale und internationale Zusammenarbeiten mit universitären und industriellen Arbeitsgruppen
- Akquise und Beratung von Projekten - auch in englischer Sprache
Schwerbehinderte Bewerberinnen und Bewerber werden bei gleicher Eignung und Befähigung bevorzugt berücksichtigt.
Frauen werden nachdrücklich aufgefordert, sich zu bewerben.
Bei Rückfragen wenden Sie sich bitte an Herrn Prof. Dr. Andreas Simm, Tel.: 0345 557-2647, Fax: 0345 5577070, E-Mail: andreas(dot)simm(at)uk-halle(dot)de
Ihre Bewerbung richten Sie bitte unter Angabe der Reg.-Nr.: 7-059/17-H mit den üblichen Unterlagen bis zum 18.04.2017 an die Martin-Luther-Universität Halle-Wittenberg, Medizinische Fakultät, Zentrum für Medizinische Grundlagenfoschung, Ernst-Grube Str. 40, 06120 Halle (Saale).
Die Ausschreibung erfolgt unter Vorbehalt eventueller haushaltsrechtlicher Restriktionen. Bewerbungskosten werden von der Martin-Luther-Universität nicht erstattet. Bewerbungsunterlagen werden nur zurückgesandt, wenn ein ausreichend frankierter Rückumschlag beigefügt wurde. Eine elektronische Bewerbung ist möglich.
Postdoc: Chemical biomarkers of genotoxicity
We are searching for postdoctoral scientists to join the Laboratory of Toxicology at the ETH Zurich. The lab is headed by
Prof. Shana J. Sturla and our main goal is to understand the chemical basis of mutagenesis and toxicity. Postdoctoral scientists who join our lab have diverse backgrounds in chemistry and biology and work on projects concerning DNA damage and mutation, biomarkers, gut microbiota, and systems-wide molecular alterations in cells. We use a variety of experimental approaches, for example, mass spectrometry-based protein, metabolite and DNA adduct measurements, synthesizing novel small molecules and nucleic acids, and carrying out in vitro toxicological assays. We are particularly interested in candidates with experience regarding genome sequencing or mass spectrometry.
We are seeking scientists with strong leadership potential, high motivation, and excellent communication skills in English. Inquiries should be sent to Prof. Sturla at sturlas(at)ethz(dot)ch and should include a CV and describe (1) scientific interests and how your previous experiences have synergy with research of our lab, and (2) your long-term career goals.
We also have opportunities for PhD students. Information and the on-line application can be found at www.jobs.ethz.ch by searching for “toxicology”.
Postdoctoral position in breath metabolomics & translational medicineUni
The University Children’s Hospital Basel, University of Basel (Switzerland)
The project involves the application of novel mass spectrometric techniques to phenotype lung diseases and therapeutic monitoring via breath analysis. The research activities will be implemented at the University Children's hospital Basel. The research fellow will join an emergent multidisciplinary research group affiliated to a newly appointed professor (Prof. Pablo M-L Sinues) at the University of Basel.
Experience in mass spectrometry and background in related areas such as bioinformatics (Matlab/R programming is preferred).
Cover letter, CV and coordinates of references should be submitted as one single *.pdf file by email to Prof. Sinues at pablo(dot)mlsinues(at)org(dot)chem(dot)ethz(dot)ch
About the employer:
Basel is a very international city and a center of life science research, with over 900 life science research companies in the area, including Novartis and Roche. Several other academic institutions are also in the city, including the Friedrich Miescher Institute, the ETH Zurich Biosystems Science and Engineering Department and the Swiss Tropical Institute. The city is less than 5km from both France and Germany and an hour and a half from the Swiss Alps.
Research Scientist - Mass Spectrometry
Location: Parkville, Victoria, Australia
Full time permanent role Located at Bio21 Institute ( Melbourne, Australia) CSL5
As a Research Scientist- Analytical Biochemistry you will join CSL’s Research Group and be responsible for providing internationally competitive mass spectrometry capabilities in this vital laboratory–based role. You will implement innovative techniques for the in-depth analysis of biopharmaceutical therapeutics using your expert knowledge of post-translational modifications of proteins and their method of analysis. Your extensive knowledge in mass spectrometric techniques in combination with a wide variety of separation methods, for detailed characterisation of complex modified proteins will be an asset. If you are a proactive person having excellent attention to detail and want to be part of a growing organisation this could be your next long term role working in the heart of Melbourne.
- Develop MS based techniques for structural characterisation of recombinant proteins
- Identify post-translational modifications and their associated heterogeneities with
- particular emphasis on those affecting structure and function
- Perform general mass spectrometry tasks as per requirements
- Develop and manage the bioinformatics needs of the group
- Maintain current awareness of key scientific/technical strategies and innovative
- technological developments in mass spectrometry
- Lead and oversee experimental work in areas assigned as those of direct responsibility
- by principal Director analytical biochemistry or as agreed with Director and other
- team members
- Present results of laboratory work to internal and external collaborators as needed to
- facilitate smooth progress of CSL R&D projects
- Ensure that day to day activities are carried so as to comply with CSL’s
- environmental goals
- Ensure role is carried out to comply with CSL’s HSE policies
To be Successful
- Ph.D. or equivalent in Biochemistry or a related field
- Significant experience operating mass spectrometry instruments and associated
- Significant and extensive expertise in operating and maintaining mass spectrometry instrumentation, particularly as applied to protein, peptide and glycan analysis (e.g. ESI-MS/MS, MALDI-MS/MS, good knowledge of qTOF’s, QqQ and Orbitrap instruments)
- Demonstrated experience in multidimensional chromatography, 1- and 2-D gel electrophoresis
- Proficient in mass spectrometry data analysis tools
- Experience with all commonly used homology and MS search engines
- Experience in identifying post-translational modifications
- Strong protein chemistry knowledge
- Demonstrated ability to write scientific reports and publications.
- Ability and willingness to work in a collaborative capacity.
- Effective time management
- Ability to work enthusiastically as part of a team
Applications close 5.00pm AEST 31 March 2017.
Employment screening, including criminal history, medical assessment, confirmation of experience and stated qualifications, Australian working rights and other relevant checks form part of the candidate suitability evaluation process.
- Mid-Senior level
Postgraduate in Mass Spectrometry
Job description extract
We have an immediate opening for a highly motivated postgraduate to support IBP in developing mass spectrometry-based analytical methods for the characterization of bio therapeutics including monoclonal antibodies, antibody drug conjugates.
Main tasks will be the following:
- Analysis of proteins using chromatography coupled with mass spectrometry
- Development of analytical methods for the characterization of biotherapeutics
- Data analysis and interpretation
Graduate/Masters with specialization in analytical chemistry or biochemistry or biotechnology. Good understanding of protein analysis and mass spectrometry.
Duration of employment
Internship for 18 months
Please find the full job description to submit your complete application online on the Novartis Career website: www.novartis.com/careers
Job ID 205109BR.
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